Research progress on stimulator of interferon genes (STING) agonists

VernacularTitle:干扰素基因刺激因子激动剂的研究进展
Author: Qian YANG ¹ ; Nannan CHEN ; Qidong YOU ; Xiaoli XU
Author Information

1. 国家知识产权局专利局专利审查协作北京中心
Publication Type:Journal Article
Keywords: stimulator of interferon genes (STING); agonists; tumor immunotherapy; structural modifications; mode of action; advance
From: Journal of China Pharmaceutical University 2022;53(3):253-263
CountryChina
Language:Chinese
Abstract: Stimulator of interferon genes (STING) is an important factor in the auto-immune response of our bodies.Considering the mechanism of activating CD8+ T cells after the activation of STING protein, the combination of STING agonists and immune checkpoint inhibitors for the treatment of tumor immunotherapy has good clinical application prospect.In this paper, the research progress of molecular types, mechanism of action and structural modifications of STING agonists were reviewed.The developing tendency were outlined to provide some references for further investigation.