Megastigmanes from an aqueous extract of Uncaria rhynchophylla
10.16438/j.0513-4870.2022-0373
- VernacularTitle:钩藤水提取物中megastigmane类成分
- Author:
Le-ling SONG
;
Yue WANG
;
Ruo-fei LI
;
Cheng-gen ZHU
;
Qing-lan GUO
;
Jian-gong SHI
- Publication Type:Research Article
- Keywords:
Rubiaceae;
italic>Uncaria;
italic>Uncaria rhynchophylla;
megastigmanes;
new natural product
- From:
Acta Pharmaceutica Sinica
2022;57(6):1832-1839
- CountryChina
- Language:Chinese
-
Abstract:
Five new megastigmanes (1-5) were isolated from a decoction of Uncaria rhynchophylla by separation techniques of column chromatography using a combination of multiple stationary phases, including macroporous adsorbent resin, MCI resin, silica gel, Sephadex LH-20, and Toyopearl HW-40F, and reversed phase HPLC. Their structures were characterized by spectroscopic data analysis of HR-ESI-MS, NMR, and CD, in combination with Mosher's mothed as well as ECD and NMR calculations. The new compounds were named uncarphyllonone A (1), uncarphyllonols A (2) and B (3), and uncarphabscisic acids A (4) and B (5). Although the structures of 3 and 4 were previously reported, the reported NMR spectroscopic data were incorrect or do not support the assigned structures in literatures. This is also the first report of discovery of new megastigmane natural products from the Uncaria genus.
