Research progress of iron metabolism and its mechanism in the treatment of heart failure
10.16438/j.0513-4870.2022-0268
- VernacularTitle:铁代谢及其在心力衰竭治疗中的作用机制研究进展
- Author:
Xiao-li WEI
;
Ji-chao ZHOU
;
Xiao-wei ZHANG
- Publication Type:Research Article
- Keywords:
iron deficiency;
iron overload;
heart failure;
antioxidation;
mitochondria
- From:
Acta Pharmaceutica Sinica
2022;57(6):1584-1592
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of heart failure is a complex progression and associated with abnormal regulation of many signaling pathways. As a cofactor of hemoglobin, myoglobin, oxidative respiratory chain, DNA synthase and other important proteins, iron plays an indispensable role in myocardial energy metabolism. Recently, a large number of studies have shown that heart failure is related to the disorder of iron metabolism. Both iron deficiency and iron overload can lead to the development of a variety of cardiomyopathy, and even progress to heart failure. Iron metabolism could be a key target for the diagnosis, prevention and treatment of heart failure. Here, we review the basic process of iron metabolism and its mechanism in heart failure, expecting to provide new clues and evidence for the treatment of heart failure.
