Research progress on mitochondrial oxidative stress and corresponding targeted delivery systems in Alzheimer's disease
10.16438/j.0513-4870.2022-0263
- VernacularTitle:阿尔茨海默病的线粒体氧化应激及靶向递送系统研究进展
- Author:
Ling-ling ZHOU
;
Kang QIAN
;
Peng YANG
;
Qi-zhi ZHANG
- Publication Type:Research Article
- Keywords:
mitochondrial oxidative stress;
Alzheimer's disease;
neuron;
rug delivery system;
italic>β-amyloid;
tau protein
- From:
Acta Pharmaceutica Sinica
2022;57(6):1630-1640
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial oxidative stress has been recognized as a preliminary and critical factor that aggravates the pathological cascade of Alzheimer's disease, which induces the production of β-amyloid protein, upregulates the expression of phosphorylated tau protein and triggers oxidative damage to lipids, proteins and mitochondrial deoxyribonucleic acid. Central neurons are more vulnerable to oxidative stress than non-neuronal cells due to their high oxygen demand, abundant unsaturated fatty acids and antioxidant enzymes deficiency. On this account, this review introduces the causes of mitochondrial oxidative stress, and analyzes the important role of mitochondrial oxidative stress in the pathogenesis of Alzheimer's disease. Meanwhile, the review focuses on the design and intervention strategies of drug delivery systems targeting mitochondrial oxidative stress in neurons, aiming to provide new ideas for the prevention and treatment of Alzheimer's disease.
