Ferroptosis of airway epithelial cells in asthma: current and future

VernacularTitle:气道上皮细胞铁死亡在哮喘中的作用: 现状与展望
Author: Xue-mei CHEN ^{1
,

2} ; Juan LIANG ^{1
,

2} ; Xiu-ling SONG ^{1
,

2} ; Xiao-hua LIU ^{1
,

2} ; Chu-peng XUE ^{1
,

2} ; Yu-ge HUANG ¹ ; Wen LI ¹
Author Information

1. Department of Pediatric, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
2. Graduate School of Guangdong Medical University, Zhanjiang 524001, China
Publication Type:Research Article
Keywords: asthma; airway epithelial cell; ferroptosis; lipid peroxidation; iron; antioxidant system
From: Acta Pharmaceutica Sinica 2022;57(6):1614-1620
CountryChina
Language:Chinese
Abstract: Ferroptosis is a novel cell death mode proposed in recent years, which is characterized by intracellular iron-dependent lipid peroxidation. Its mechanisms include lipid peroxidation, iron accumulation and the imbalance of antioxidant system. The crosstalk between ferroptosis and asthma is gradually deepening. Elucidating the specific mechanism of ferroptosis in regulating asthma is helpful to broaden the understanding of the pathology of asthma. This paper expounds the role of ferroptosis in airway epithelial cells in the occurrence and development of asthma from three perspectives: lipid peroxidation, iron accumulation and the imbalance of antioxidant system, hoping to find new targets and strategies for asthma treatment.