The NO inhibitory constituents from Illigera rhodantha
10.16438/j.0513-4870.2022-0035
- VernacularTitle:壮药红花青藤中抑制NO生成的活性成分研究
- Author:
Jie GAN
;
Wei WEI
;
Jin-ni TAN
;
Meng-ru SHEN
;
Qin-gang TAN
- Publication Type:Research Article
- Keywords:
Hernandiaceae;
italic>Illigera rhodantha;
chemical constituent;
NO inhibitory activity
- From:
Acta Pharmaceutica Sinica
2022;57(6):1849-1854
- CountryChina
- Language:Chinese
-
Abstract:
Sixteen compounds were isolated from the ethanol extract of Illigera rhodantha by silica gel, ODS, and Sephadex LH-20 column chromatographies. These compounds were identified as (2R,3R)-2,3-dihydroxy-2-methylbutane-1,4-diyldibenzoate (1), p-hydroxyphenethyl trans-ferulate (2), 4-O-benzoyl-2-C-methyl-D-erythritol (3), N-trans feruloyl-3-methyldopamine (4), tribulusamide A (5), cryptomeridiol (6), teuclatriol (7), oleanolic acid (8), icario A2 (9), vanillic acid (10), p-hydroxybenzoic acid (11), gallic acid (12), ethyl gallate (13), chrysophanol (14), D-1-O-methyl-inositol (15), and hexadecanoic acid (16) based on their spectral data and physico-chemical properties. Compound 1 is an undescribed compound, of which its absolute configurations were determined by Mosher and ROESY methods; all the compounds except 10, 11 and 14 were isolated from Illigera genus for the first time. Compared with the positive control indomethacin, compounds 4-6, 8 and 9 inhibited significantly against the NO production in LPS-induced RAW 264.7 cells.
