Progress of discovery of molecular glues from natural products and their derivatives
10.16438/j.0513-4870.2021-1805
- VernacularTitle:基于天然产物及其衍生物的分子胶水的研究进展
- Author:
Jia HE
;
Kun-ling SONG
;
Zu-feng GUO
;
Yong-jun DANG
- Publication Type:Research Article
- Keywords:
molecular glue;
natural product;
protein-protein interaction
- From:
Acta Pharmaceutica Sinica
2022;57(6):1702-1710
- CountryChina
- Language:Chinese
-
Abstract:
Molecular glues are a class of small molecules that induce the formation of protein-protein interactions to confer new biological function or therapeutic effects. As a unique pharmacological modality, molecular glues could target proteins without druggable binding pockets. It exhibits a variety of functions, including regulating signal transduction, stabilization or degradation of targeted proteins, through sticking different proteins together. This review will summarize the development and current status of molecular glues derived from natural products and analogs by illustrating the discovery and interaction mechanism. We hope to present a systematic view, provide valuable clues for researchers and encourage them to explore more efficient and rational molecular glue discovery strategies.
