Research progress of natural products for the treatment of hyperuricemia and gout
10.16438/j.0513-4870.2021-1715
- VernacularTitle:具有降尿酸或抗痛风活性的天然产物研究进展
- Author:
Zhi-jiao ZHANG
;
Rui-peng LIANG
;
Tong ZHAO
;
Shu-jing XU
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
natural product;
gout;
hyperuricemia;
uric acid;
rug discovery
- From:
Acta Pharmaceutica Sinica
2022;57(6):1679-1688
- CountryChina
- Language:Chinese
-
Abstract:
Although current synthetic anti-gout drugs have significant therapeutic effects in reducing serum uric acid levels, they have serious side effects such as allergic reactions and liver and kidney damage. Natural products with a wide range of uric acid-lowering and high safety have played a critical role in anti-gout drug discovery and development. This paper reviews the natural products with uric acid-lowering or anti-gout pharmacological effects and the investigation on their mechanisms of action, to provide information for drug discovery and development.
