Research progress of silk fibroin-based nanoparticulate drug delivery systems
10.16438/j.0513-4870.2021-1662
- VernacularTitle:基于丝素蛋白的纳米粒药物递送系统研究进展
- Author:
Zhi-yang CHEN
;
Jun YE
;
Hong-liang WANG
;
Yan-fang YANG
;
Jia-ling CHENG
;
Hang ZHOU
;
Yu-ling LIU
- Publication Type:Research Article
- Keywords:
silk fibroin;
natural polymer;
carrier material;
nanoparticle;
rug delivery system
- From:
Acta Pharmaceutica Sinica
2022;57(6):1792-1800
- CountryChina
- Language:Chinese
-
Abstract:
Silk fibroin is a natural polymer with certain water solubility, structural modification, good biocompatibility and biodegradability, which can be used as a drug delivery carrier material. As a promising drug delivery system, drug-loaded silk fibroin nanoparticles can control drug release, reduce toxicity and improve therapeutic effects. In this paper, the basic characteristics of silk fibroin, the preparation methods of drug-loaded silk fibroin nanoparticles and the application of silk fibroin in nanoparticulate drug delivery systems are reviewed, and on this basis, the further development of drug-loaded silk fibroin nanoparticles is prospected.
