Novel strategies for promoting tumor penetration of anticancer nanomedicines
10.16438/j.0513-4870.2021-1330
- VernacularTitle:促进抗癌纳米药物肿瘤渗透的新型策略
- Author:
Jing HUANG
;
Jun-na ZOU
;
Huan-huan REN
;
Shan WANG
- Publication Type:Research Article
- Keywords:
nanomedicine;
tumor microenvironment;
tumor penetration;
transcytosis;
immune cell
- From:
Acta Pharmaceutica Sinica
2022;57(6):1758-1770
- CountryChina
- Language:Chinese
-
Abstract:
There is a broad and urgent need for the clinical application of anticancer nanomedicine in tumor therapy, but the complex biological barrier in solid tumors has always been the main obstacle to infiltrating nanomedicine into the tumor. The traditional design of nanomedicine based on enhanced permeability and retention (EPR) effect still has some limitations in tumor permeability, it is urgent to find other design theories. Therefore, this review summarizes two novel strategies, active transcytosis and immune cell-mediated tumor penetration, for promoting tumor penetration of anticancer nanomedicine.
