Research advances of photosensitizer in photodynamic therapy of glioblastoma
10.16438/j.0513-4870.2021-1248
- VernacularTitle:光敏剂在胶质母细胞瘤光动力治疗中的研究进展
- Author:
Hong-cheng ZHAO
;
Yue-qing WANG
;
Qing-yun LI
;
Hao DENG
;
Xiao TAN
;
Xiao-wen LIU
- Publication Type:Research Article
- Keywords:
photosensitizer;
glioblastoma;
photodynamic therapy;
adjuvant therapy;
clinical application
- From:
Acta Pharmaceutica Sinica
2022;57(6):1750-1757
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma is a malignant tumor in central nervous system, which has strong invasion, poor prognosis and short survival time. At present, the main treatment strategy of glioblastoma is surgical excision, supplemented by radiotherapy and chemotherapy. However, due to incomplete resection and high recurrence rate, it is urgent to find novel therapeutic method for glioblastoma. Photodynamic therapy, as a promising non-surgical treatment, provides a new strategy for postoperative adjuvant therapy of glioblastoma. This review summarizes the mechanism and clinical application of photodynamic therapy mediated by various photosensitizers in glioblastoma, in order to provide help for the treatment of glioblastoma.
