Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism.
10.1016/j.apsb.2021.11.008
- Author:
Abi MAHARJAN
1
;
Hongyu SUN
1
;
Zeying CAO
1
;
Ke LI
2
;
Jinping LIU
3
;
Jun LIU
1
;
Tiqiao XIAO
4
;
Guanyun PENG
4
;
Junqiu JI
5
;
Peter YORK
1
;
Balmukunda REGMI
6
;
Xianzhen YIN
1
;
Jiwen ZHANG
1
;
Li WU
1
Author Information
1. Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2. University of Chinese Academy of Sciences, Beijing 100049, China.
3. Hefei Lifeon Medication Group, Hefei 230088, China.
4. Shanghai Synchrotron Radiation Facility/Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China.
5. Center for MOST and Image Fusion Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
6. Maharajgung Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu 44606, Nepal.
- Publication Type:Journal Article
- Keywords:
Bilayer osmotic pump tablet;
Peripheral “roadways”;
Push-pull model;
Release kinetics;
Subterranean river model;
Synchrotron radiation micro-computed tomography;
Three-dimensional microstructure;
Void formation
- From:
Acta Pharmaceutica Sinica B
2022;12(5):2568-2577
- CountryChina
- Language:English
-
Abstract:
Defining and visualizing the three-dimensional (3D) structures of pharmaceuticals provides a new and important tool to elucidate the phenomenal behavior and underlying mechanisms of drug delivery systems. The mechanism of drug release from complex structured dosage forms, such as bilayer osmotic pump tablets, has not been investigated widely for most solid 3D structures. In this study, bilayer osmotic pump tablets undergoing dissolution, as well as after dissolution in a desiccated solid state were examined, and visualized by synchrotron radiation micro-computed tomography (SR-μCT). In situ formed 3D structures at different in vitro drug release states were characterized comprehensively. A distinct movement pattern of NaCl crystals from the push layer to the drug layer was observed, beneath the semi-permeable coating in the desiccated tablet samples. The 3D structures at different dissolution time revealed that the pushing upsurge in the bilayer osmotic pump tablet was directed via peripheral "roadways". Typically, different regions of the osmotic front, infiltration region, and dormant region were classified in the push layer during the dissolution of drug from tablet samples. According to the observed 3D microstructures, a "subterranean river model" for the drug release mechanism has been defined to explain the drug release mechanism.
