Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases.
10.1016/j.apsb.2021.09.025
- Author:
Yesi SHI
1
;
Hongyan QIAN
2
;
Peishi RAO
2
;
Dan MU
1
;
Yuan LIU
2
;
Gang LIU
1
;
Zhongning LIN
1
Author Information
1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
2. Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361102, China.
- Publication Type:Review
- Keywords:
Autoimmune;
Bioengineering;
Biomimetic membrane;
Immune system;
Immunotherapy;
Infectious diseases;
Nanomodulators
- From:
Acta Pharmaceutica Sinica B
2022;12(3):1126-1147
- CountryChina
- Language:English
-
Abstract:
Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases, which involve plenty of immune cells, pathogens and autoantibodies. Nanomedicine has a great potential in modulating immune system. Particularly, biomimetic nanomodulators can be designed for prevention, diagnosis and therapy to achieve a better targeted immunotherapy. With the development of materials science and bioengineering, a wide range of membrane-coated nanomodulators are available. Herein, we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious diseases. We also rethink the challenges or limitations in the progress of the therapeutic nanoplatform, and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.
