Pharmaceutical applications of framework nucleic acids.
10.1016/j.apsb.2021.05.022
- Author:
Liang CHEN
1
;
Jie ZHANG
1
;
Zhun LIN
1
;
Ziyan ZHANG
1
;
Miao MAO
1
;
Jiacheng WU
1
;
Qian LI
2
;
Yuanqing ZHANG
1
;
Chunhai FAN
2
Author Information
1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
2. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
- Publication Type:Review
- Keywords:
DNA nanostructures;
DNA nanotechnology;
Drug analysis;
Drug delivery;
Drug discovery;
Framework nucleic acids;
Self-assembly;
Therapeutic molecules
- From:
Acta Pharmaceutica Sinica B
2022;12(1):76-91
- CountryChina
- Language:English
-
Abstract:
DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids (FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future.
