Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy.
10.1016/j.apsb.2021.08.026
- Author:
Jinjing WEI
1
;
Yongting ZHAO
2
;
Haihai LIANG
3
;
Weijie DU
3
;
Lihong WANG
1
Author Information
1. Department of Endocrinology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
2. Department of Endocrinology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
3. Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China.
- Publication Type:Review
- Keywords:
Aautosis;
Apoptosis;
Autophagic cell death;
Cell death;
Diabetes mellitus;
Diabetic cardiomyopathy;
Ferroptosis;
Necroptosis;
Pyroptosis
- From:
Acta Pharmaceutica Sinica B
2022;12(1):1-17
- CountryChina
- Language:English
-
Abstract:
Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications (DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy (DCM) as the most common DCC. The metabolic disturbance in DCM generates the conditions/substrates and inducers/triggers and activates the signaling molecules and death executioners leading to cardiomyocyte death which accelerates the development of DCM and the degeneration of DCM to heart failure. Various forms of programmed active cell death including apoptosis, pyroptosis, autophagic cell death, autosis, necroptosis, ferroptosis and entosis have been identified and characterized in many types of cardiac disease. Evidence has also been obtained for the presence of multiple forms of cell death in DCM. Most importantly, published animal experiments have demonstrated that suppression of cardiomyocyte death of any forms yields tremendous protective effects on DCM. Herein, we provide the most updated data on the subject of cell death in DCM, critical analysis of published results focusing on the pathophysiological roles of cell death, and pertinent perspectives of future studies.
