Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats.
10.1016/S1875-5364(22)60175-4
- Author:
Xin-Sen WANG
1
;
Ming-Xin HU
1
;
Qing-Xiang GUAN
1
;
Li-Hui MEN
2
;
Zhong-Ying LIU
3
Author Information
1. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
2. College of Basic Medical Sciences, Jilin University, Changchun 130021, China. Electronic address: murielle.menlh@jlu.edu.cn.
3. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. Electronic address: murielle.liuzy@jlu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Metabolomics;
Panax ginseng C. A. Mey;
Type 1 diabetes
- MeSH:
Animals;
Biomarkers;
Chromatography, High Pressure Liquid/methods*;
Diabetes Mellitus, Experimental/metabolism*;
Diabetes Mellitus, Type 1/drug therapy*;
Kidney;
Metabolomics/methods*;
Panax/chemistry*;
Plant Extracts/pharmacology*;
Rats
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(5):378-386
- CountryChina
- Language:English
-
Abstract:
The dry root and rhizome of Panax ginseng C. A. Mey has garnered much interest owing to its medicinal properties against diabetes and cardiovascular diseases. In this study, an ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS)-based metabolomics approach was used to illustrate the therapeutic mechanisms of ginseng extract on the serum and urinary metabolic profiles in streptozotocin-induced type 1 diabetes mellitus (T1DM) rats. Pharmacological and renal parameters in response to the administration of ginseng were also evaluated. In total, 16 serum endogenous metabolites and 14 urine endogenous metabolites, including pyruvic acid, indoleacetic acid, and phenylacetylglycine, were identified as potential biomarkers for diabetes. Pathway enrichment and network analysis revealed that the biomarkers modulated by ginseng were primarily involved in phenylalanine and pyruvate metabolism, as well as in arginine biosynthesis. Moreover, the levels of several renal injury-related biomarkers in T1DM rats were significantly restored following treatment with ginseng. The administration of the extract helped maintain tissue structure integrity and ameliorated renal injury. The findings suggest that the regulatory effect of ginseng extract on T1DM involves metabolic management of diabetic rats, which subsequently attenuates T1DM-induced early renal dysfunction.
