Polyhydroxylated eudesmane sesquiterpenoids and sesquiterpenoid glucoside from the flower buds of Tussilago farfara.
10.1016/S1875-5364(21)60120-6
- Author:
Yu-Peng LI
1
;
Kang YANG
2
;
Hui MENG
2
;
Tao SHEN
2
;
Hua ZHANG
3
Author Information
1. School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
2. Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
3. School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Eudesmane sesquiterpenoid;
NO production inhibition;
Quinic acid derivative;
Tussilago farfara
- MeSH:
Animals;
Flowers/chemistry*;
Glucosides/pharmacology*;
Mice;
Sesquiterpenes/pharmacology*;
Sesquiterpenes, Eudesmane/pharmacology*;
Tussilago/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(4):301-308
- CountryChina
- Language:English
-
Abstract:
Chemical fractionation of the n-BuOH partition, which was generated from the EtOH extract of the flower buds of Tussilago farfara, afforded a series of polar constituents including four new sesquiterpenoids (1-4), one new sesquiterpenoid glucoside (5) and one known analogue (6) of the eudesmane type, as well as five known quinic acid derivatives (7-11). Structures of the new compounds were unambiguously characterized by detailed spectroscopic analyses, with their absolute configurations being established by X-ray crystallography, electronic circular dichroism (ECD) calculation and induced ECD experiments. The inhibitory effect of all the isolates against LPS-induced NO production in murine RAW264.7 macrophages was evaluated, with isochlorogenic acid A (7) showing significant inhibitory activity.
