Promising natural lysine specific demethylase 1 inhibitors for cancer treatment: advances and outlooks.
10.1016/S1875-5364(22)60141-9
- Author:
Zhong-Rui LI
1
,
2
;
Meng-Zhen GU
3
;
Xiao XU
3
;
Jing-Han ZHANG
3
;
Hai-Li ZHANG
3
;
Chao HAN
4
Author Information
1. Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China
2. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
3. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
4. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: hanchao@cpu.edu.cn.
- Publication Type:Review
- Keywords:
Anticancer;
Histone lysine demethylase;
LSD1 inhibitor;
Natural product
- MeSH:
Antineoplastic Agents/therapeutic use*;
Enzyme Inhibitors/therapeutic use*;
Histone Demethylases/metabolism*;
Humans;
Lysine/therapeutic use*;
Neoplasms/drug therapy*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(4):241-257
- CountryChina
- Language:English
-
Abstract:
Lysine specific demethylase 1 (LSD1), a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9, has become a potential therapeutic target for cancer therapy. LSD1 mediates many cellular signaling pathways and regulates cancer cell proliferation, invasion, migration, and differentiation. Recent research has focused on the exploration of its pharmacological inhibitors. Natural products are a major source of compounds with abundant scaffold diversity and structural complexity, which have made a major contribution to drug discovery, particularly anticancer agents. In this review, we briefly highlight recent advances in natural LSD1 inhibitors over the past decade. We present a comprehensive review on their discovery and identification process, natural plant sources, chemical structures, anticancer effects, and structure-activity relationships, and finally provide our perspective on the development of novel natural LSD1 inhibitors for cancer therapy.