New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum.
10.1016/S1875-5364(21)60116-4
- Author:
Yu-Dan ZHAO
1
;
Xin ZHANG
1
;
Wan-Yue YANG
1
;
Rui-Qi ZHANG
1
;
Lin-Tong MU
1
;
Ling HAN
2
;
Chong-Ning LV
3
,
4
;
Jin-Cai LU
3
,
5
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi 117004, China.
3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
4. Liaoning Provincial Key Laboratory of TCM Resources Conservation and Development, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: lcnmi@outlook.com.
5. Liaoning Provincial Key Laboratory of TCM Resources Conservation and Development, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: jincailu@syphu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-pulmonary fibrosis;
Epimedium koreanum;
Prenylflavonoid glycoside
- MeSH:
Chromatography, High Pressure Liquid;
Epimedium/chemistry*;
Glycosides/pharmacology*;
Plant Extracts/pharmacology*;
Plant Leaves/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(3):221-228
- CountryChina
- Language:English
-
Abstract:
Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties, which were two extremely rare sugar units from the genus Epimedium. The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line. Compounds 1, 2 and 4 showed significant anti-pulmonary fibrosis activities.
