Sesquiterpenoids from the leaves of Sarcandra glabra.
10.1016/S1875-5364(21)60102-4
- Author:
Yong-Yue WANG
1
;
Qiu-Rong LI
1
;
Jun CHI
1
;
Ji-Xin LI
1
;
Ling-Yi KONG
2
;
Jun LUO
3
Author Information
1. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
3. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojun@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
N-containing sesquiterpenoids;
Sarcandra glabra;
Sesquiterpenoids
- MeSH:
Molecular Structure;
Plant Leaves;
Polycyclic Sesquiterpenes;
Seeds;
Sesquiterpenes/pharmacology*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(3):215-220
- CountryChina
- Language:English
-
Abstract:
Sarglanoids A-F, six new sesquiterpenoids belonging to eudesmane (1-5) and eremophilane (6) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Compounds 1-2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μmol·L-1. These findings provide scientific evidence for sesquiterpenoids as the material foundation of S. glabra.
