Bioactive neolignans and lignans from the roots of Paeonia lactiflora.
10.1016/S1875-5364(22)60164-X
- Author:
Huan XIA
1
;
Jing-Fang ZHANG
2
;
Ling-Yan WANG
2
;
Gui-Yang XIA
1
;
Ya-Nan WANG
2
;
Yu-Zhuo WU
1
;
Peng-Cheng LIN
3
;
Liang XIONG
4
;
Sheng LIN
5
Author Information
1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
3. College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China. Electronic address: qhlpc@126.com.
4. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: xiling@cdutcm.edu.cn.
5. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. Electronic address: lsznn@126.com.
- Publication Type:Journal Article
- Keywords:
Human carboxylesterase 2A1;
Lignan;
Neolignan;
Paeonia lactiflora
- MeSH:
Chromatography, High Pressure Liquid;
Humans;
Lignans/chemistry*;
Paeonia;
Plant Roots/chemistry*;
Stereoisomerism
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(3):210-214
- CountryChina
- Language:English
-
Abstract:
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 μmol·-1.
