Sinkihwan-gamibang ameliorates puromycin aminonucleoside-induced nephrotic syndrome.
10.1016/S1875-5364(22)60142-0
- Author:
Hyeon Kyoung LEE
1
,
2
;
Youn Jae JANG
1
,
2
;
Se Won NA
1
,
2
;
Hye Yoom KIM
1
,
2
;
Byung Hyuk HAN
1
,
2
;
Yun Jung LEE
1
,
2
;
Ho Sub LEE
1
,
2
;
Jung Joo YOON
1
,
3
;
Dae Gill KANG
1
,
4
Author Information
1. Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Jeollabukdo 54538, Republic of Korea
2. College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Jeollabukdo 54538, Republic of Korea.
3. College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Jeollabukdo 54538, Republic of Korea. Electronic address: mora16@naver.com.
4. College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Jeollabukdo 54538, Republic of Korea. Electronic address: dgkang@wku.ac.kr.
- Publication Type:Journal Article
- Keywords:
Fibrosis;
NLRP3 inflammasome;
Nephrotic syndrome;
Puromycin aminonucleoside;
Renal dysfunction;
Sinkihwan-gamibang
- MeSH:
Animals;
Kidney;
Male;
Nephrotic Syndrome/drug therapy*;
Proteinuria/metabolism*;
Puromycin Aminonucleoside/toxicity*;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(3):177-184
- CountryChina
- Language:English
-
Abstract:
Nephrotic syndrome (NS) is a kidney disease characterized by hypertriglyceridemia, massive proteinuria, hypo-albuminemia and peripheral edema. Sinkihwan-gamibang (SKHGMB) was recorded in a traditional Chinese medical book named "Bangyakhappyeon ()" and its three prescriptions Sinkihwan, Geumgwe-sinkihwan, and Jesaeng-sinkihwan belong to Gamibang. This study confirmed the effect of SKHGMB on renal dysfunction in an NS model induced by puromycin aminonucleoside (PAN). The experimental NS model was induced in male Sprague Dawley (SD) rats through injection of PAN (50 mg·kg-1)via the femoral vein. SKHGMB not only reduced the size of the kidneys increased due to PAN-induced NS, but also decreased proteinuria and ascites. In addition, SKHGMB significantly ameliorated creatinine clearance, creatinine, and blood urea nitrogen. SKHGMB relieved glomeruli dilation and tubules fibrosis in the glomeruli of the NS model. SKHGMB inhibited the protein and mRNA levels of the NLRP3 inflammasome including NLRP3, ASC, and pro-caspase-1 in NS rats. SKHGMB reduced the protein and mRNA levels of fibrosis regulators in NS rats. The results indicated that SKHGMB exerts protective effects against renal dysfunction by inhibiting of renal inflammation and fibrosis in NS rats.
