Old fusidane-type antibiotics for new challenges: Chemistry and biology.
10.1016/S1875-5364(21)60114-0
- Author:
Chuan TIAN
1
;
Ke WANG
1
;
Xuan ZHANG
2
;
Gang LI
3
;
Hong-Xiang LOU
4
,
5
Author Information
1. Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266071, China.
2. Shandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
3. Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266071, China. Electronic address: gang.li@qdu.edu.cn.
4. Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266071, China
5. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: louhongxiang@sdu.edu.cn.
- Publication Type:Review
- Keywords:
Biological activity;
Biosynthesis;
Fusidane-type antibiotics;
Fusidic acid;
Structural modification
- MeSH:
Anti-Bacterial Agents/pharmacology*;
Bacteria;
Biology;
Structure-Activity Relationship
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(2):81-101
- CountryChina
- Language:English
-
Abstract:
The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections untreatable now and in the future. To deal with these "new challenges", scientists tend to re-pick up "old antibiotics". Fusidane-type antibiotics have been known for nearly 80 years as potent antibacterial agents against gram-positive bacteria, especially Staphylococci, and represent the only triterpene-derived antibiotic class in clinical setting. These attractive characteristics have drawn renewed attention on fusidane-type antibiotics in recent decades. Isolation, characterization, biological evaluation, as well as chemical modifications of fusidane-type antibiotics are increasingly being reported. Combinatorial biosynthesis of this type of antibiotics has been successfully utilized not only for elucidating the biosynthetic pathways, but also for expanding their structural diversity. Some isolated and synthetic compounds exhibit comparable or even more potent biological activity than fusidic acid. This review provides an overview of progress on the studies of structure and biology of fusidane-type antibiotics from 1943 to April 2021. The informative structure-activity relationship is also highlighted.
