Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities.
10.1016/S1875-5364(21)60103-6
- Author:
Xiang-Jian ZHONG
1
;
Na ZHOU
1
;
Xin WANG
1
;
Jin-Jie LI
1
;
Hui MA
2
;
Yue JIAO
1
;
Jia-Hui XU
1
;
Peng-Cheng LIN
3
;
Xiao-Ya SHANG
4
Author Information
1. Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
2. Shandong Institute for Product Quality Inspection, Jinan 250100, China.
3. Key Laboratory for Qinghai-Tibet Plateau Phytochemistry of Qinghai Province, Qinghai Nationalities University, Xining 810000, China.
4. Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. Electronic address: shangxiaoya@buu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Biological activity;
Isolation and purification;
Rosmarinus officinalis;
Triterpenoid
- MeSH:
Animals;
Drugs, Chinese Herbal/chemistry*;
Mice;
Molecular Structure;
Rosmarinus;
Triterpenes/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(2):155-160
- CountryChina
- Language:English
-
Abstract:
Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D- and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 μg·mL-1.
