Dysideanones F-G and dysiherbols D-E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara.
10.1016/S1875-5364(22)60161-4
- Author:
Hong-Yan LIU
1
,
2
;
Mi ZHOU
3
;
Ru-Yi SHANG
4
;
Li-Li HONG
4
;
Guang-Hui WANG
3
;
Wen-Jing TIAN
3
;
Wei-Hua JIAO
5
;
Hai-Feng CHEN
6
;
Hou-Wen LIN
1
,
7
Author Information
1. School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China
2. Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
3. School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
4. Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
5. Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Electronic address: weihuajiao@hotmail.com.
6. School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China. Electronic address: haifeng@xmu.edu.cn.
7. Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Electronic address: franklin67@126.com.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
Dysidea avara;
Marine natural products;
Marine sponge;
Sesquiterpene quinones
- MeSH:
Animals;
Dysidea/chemistry*;
Porifera;
Quinones/pharmacology*;
Sesquiterpenes/pharmacology*;
Skeleton
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(2):148-154
- CountryChina
- Language:English
-
Abstract:
Four new sesquiterpene quinone meroterpenoids, dysideanones F-G (1-2) and dysiherbols D-E (3-4), were isolated from the marine sponge Dysidea avara collected from the South China Sea. The new structures were elucidated by extensive analysis of spectroscopic data including HR-MS and 1D and 2D NMR spectra, and their absolute configurations were assigned by single-crystal X-ray diffraction and ECD calculations. Anti-inflammatory evaluation showed that dysiherbols D-E (3-4) exhibited moderate inhibitory activity on TNF-α-induced NF-κB activation in human HEK-293T cells with IC50 values of 10.2 and 8.6 μmol·L-1, respectively.
