Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity.
10.1016/S1875-5364(21)60112-7
- Author:
Yu LIU
1
;
Yun-Xia YOU
1
;
Li RAO
1
;
Qian HE
1
;
Yu SU
1
;
Yue FAN
1
;
Yi-Zhou LI
1
;
You-Kai XU
2
;
Chuan-Rui ZHANG
3
,
4
Author Information
1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.
2. Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, China.
3. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China
4. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: crzhang@cqu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-HBV activity;
Geranyl phenyl ethers;
Illicium micranthum;
Spectroscopic data
- MeSH:
Antiviral Agents/pharmacology*;
Hepatitis B Surface Antigens;
Hepatitis B e Antigens;
Illicium/chemistry*;
Phenyl Ethers
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(2):139-147
- CountryChina
- Language:English
-
Abstract:
Fourteen new geranyl phenyl ethers (1-14) along with three known compounds (15-17) were isolated from Illicium micranthum, and their structures were elucidated by comprehensive spectroscopic methods. Illimicranins A-H (1-8) were characterized as geranyl vanillin ethers, while 9 and 10 were dimethyl acetal derivatives. Illimicranins I and J (11 and 12) were rare geranyl isoeugenol ethers. Illimicranins K and L (13 and 14) represented the first example of geranyl guaiacylacetone ether and geranyl zingerone ether, respectively. Compounds 1, 2 and 15 exhibited anti-HBV (hepatitis B virus) activity against HBsAg (hepatitis B surface antigen) and HBeAg (hepatitis B e antigen) secretion, and HBV DNA replication.
