Advances in the role of natural products in human gene expression.
10.1016/S1875-5364(22)60147-X
- Author:
Gang CHEN
1
,
2
;
Di ZHOU
3
;
Cheng-Min WANG
3
;
Ning LI
4
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: liningsypharm@163.com.
- Publication Type:Review
- Keywords:
Gene expression;
Natural products;
Non-coding RNAs;
Post-transcriptional regulation
- MeSH:
Biological Products/pharmacology*;
Gene Expression;
Gene Expression Regulation;
Humans
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(1):1-8
- CountryChina
- Language:English
-
Abstract:
Natural products (NPs), especially those from traditional herbal medicines, can evidently modulate human gene expression at multiple levels, leading to a wide diversity of bioactivities. Although numerous bio-functions of NPs for human body have been found, there is little understanding about how NPs achieve it, as less attention was drawn to the definite mechnism by which NPs regulate gene expression. Furthermore, based on the rapidly advancing knowledge of mechanisms for gene regulation in recent years, newly-understood mechanisms, such as post-transcriptional regulation, are found to be involved in NP-elicited bio-effects, providing a new perspective on understanding the role of NPs in gene expression. Therefore, in the current review, we summarize the function of NPs in gene expression from the perspectives of transcriptional, post-transcriptional, and post-translational regulation, which will reinforce the understanding of NP-induced effects in gene expression and facilitate the exploration of more NPs with potential therapeutic effects.
