SARS-CoV-2 variants, immune escape, and countermeasures.
10.1007/s11684-021-0906-x
- Author:
Yi ZHANG
1
;
Haocheng ZHANG
1
;
Wenhong ZHANG
2
Author Information
1. Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, 200040, China.
2. Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, 200040, China. zhangwenhong@fudan.edu.cn.
- Publication Type:Review
- Keywords:
COVID-19;
SARS-CoV-2;
breakthrough;
immune escape;
prevention;
vaccine
- MeSH:
COVID-19/prevention & control*;
COVID-19 Vaccines;
Humans;
Pandemics/prevention & control*;
SARS-CoV-2
- From:
Frontiers of Medicine
2022;16(2):196-207
- CountryChina
- Language:English
-
Abstract:
Coronavirus disease 2019 (COVID-19) has become a global pandemic disease. SARS-CoV-2 variants have aroused great concern and are expected to continue spreading. Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully established, indicating that populations remain susceptible to infection. In this review, we summarize the literature on variants of concern and focus on the changes in their transmissibility, pathogenicity, and resistance to the immunity constructed by current vaccines. Furthermore, we analyzed relationships between variants and breakthrough infections, as well as the paradigm of new variants in countries with high vaccination rates. Terminating transmission, continuing to strengthen variant surveillance, and combining nonpharmaceutical intervention measures and vaccines are necessary to control these variants.
