Nondiabetic kidney diseases in type 2 diabetic patients.
- Author:
Ye Jin KIM
1
;
Yoo Hyung KIM
;
Ki Dae KIM
;
Kang Ryun MOON
;
Jae Ho PARK
;
Bo Mi PARK
;
Hyewon RYU
;
Dae Eun CHOI
;
Ki Ryang NA
;
Kwang Sun SUH
;
Kang Wook LEE
;
Young Tai SHIN
Author Information
1. Division of Nephrology, Department of Internal Medicine, College of Medicine, Chungnam National University Hospital, Daejeon, Korea. kwlee@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Biopsy;
Diabetic nephropathy;
Immunosuppressive agents;
Type 2 diabetes mellitus
- MeSH:
Biopsy;
Diabetes Mellitus, Type 2;
Diabetic Nephropathies;
Diabetic Retinopathy;
Follow-Up Studies;
Glomerular Filtration Rate;
Glomerulonephritis, IGA;
Glomerulonephritis, Membranous;
Humans;
Immunosuppressive Agents;
Kidney Diseases*;
Kidney*;
Nephritis, Interstitial;
Proteinuria
- From:Kidney Research and Clinical Practice
2013;32(3):115-120
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of this study was to evaluate the clinical characteristics of nondiabetic nephropathy in type 2 diabetes mellitus patients and to find a clinical significance of renal biopsy and immunosuppressive treatment in such a patient. METHODS: Renal biopsy results, clinical parameters, and renal outcomes were analyzed in 75 diabetic patients who underwent kidney biopsy at Chungnam National University Hospital from January 1994 to December 2010. RESULTS: The three most common reasons for renal biopsy were nephrotic range proteinuria (44%), proteinuria without diabetic retinopathy (20%), and unexplained decline inrena lfunction (20.0%). Ten patients (13.3%) had only diabetic nephropathy (Group I); 11 patients (14.7%) had diabetic nephropathy with superimposed nondiabetic nephropathy (Group II); and 54 patients (72%) had only nondiabetic nephropathy (Group III). Membranous nephropathy (23.1%), IgA nephropathy (21.5%), and acute tubulointerstitial nephritis (15.4%) were the three most common nondiabetic nephropathies. Group III had shorter duration of diabetes and lesser diabetic retinopathy than Groups I and II (P = 0.008).Group II had the lowest baseline estimated glomerular filtration rate (P = 0.002), with the greatest proportion of renal deterioration during follow-up (median 38.0 months, P < 0.0001). The patients who were treated with intensive method showed better renal outcomes (odds ratio 4.931; P = 0.01). Absence of diabetic retinopathy was associated with favorable renal outcome in intensive treatment group (odds ratio 0.114; P = 0.032). CONCLUSION: Renal biopsy should be recommended for type 2 diabetic patients with a typical nephropathy because a considerable number of these patients may have nondiabetic nephropathies. And intensive treatment including corticosteroid or immunosuppressants could be recommended for type 2 diabetic patients with nondiabetic nephropathy, especially if the patients do not have diabetic retinopathy.
