Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain.
10.1007/s12264-022-00844-7
- Author:
Fu-Jun ZHAI
1
;
Song-Ping HAN
2
;
Tian-Jia SONG
1
;
Ran HUO
1
;
Xing-Yu LAN
1
;
Rong ZHANG
3
;
Ji-Sheng HAN
4
Author Information
1. Neuroscience Research Institute, Peking University, Beijing, 100191, China.
2. Wuxi HANS Health Medical Technology Co., Ltd., Wuxi, 214122, China.
3. Neuroscience Research Institute, Peking University, Beijing, 100191, China. zhangrong@bjmu.edu.cn.
4. Neuroscience Research Institute, Peking University, Beijing, 100191, China. hanjisheng@bjmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Analgesia;
Dynorphin;
Endorphins;
Methionine-Enkephalin;
Opioid receptors;
SCS
- MeSH:
Analgesics;
Animals;
Narcotic Antagonists/pharmacology*;
Neuralgia/therapy*;
Opioid Peptides;
Rats;
Receptors, Opioid/physiology*;
Receptors, Opioid, kappa;
Spinal Cord;
Spinal Cord Stimulation
- From:
Neuroscience Bulletin
2022;38(4):403-416
- CountryChina
- Language:English
-
Abstract:
Spinal cord stimulation (SCS)-induced analgesia was characterized, and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats. The analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20% and 80% motor thresholds. Various frequencies (2, 15, 50, 100, 10000 Hz, and 2/100 Hz dense-dispersed) of SCS were similarly effective. SCS-induced analgesia was maintained without tolerance within 24 h of continuous stimulation. SCS at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal fluid. The analgesic effect of 2 Hz was abolished by μ or κ opioid receptor antagonist. The effect of 100 Hz was prevented by a κ antagonist, and that of 10 kHz was blocked by any of the μ, δ, or κ receptor antagonists, suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.
