Role of circular RNAs in immune-related diseases.
10.12122/j.issn.1673-4254.2022.02.01
- Author:
Weijie ZHAN
1
;
Tao YAN
2
;
Jiawen GAO
3
;
Minkai SONG
2
;
Ting WANG
4
;
Fei LIN
4
;
Haiyu ZHOU
5
;
Li LI
6
;
Chao ZHANG
4
Author Information
1. Second School of Clinical Medicine, Southern Medical University, Guangzhou 510282, China.
2. Division of Orthopedics Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
3. Division of Spine Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
4. Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510515, China.
5. Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
6. College of Basic Medicine and Life Sciences, Hainan Medical University, Haikou 571199, China.
- Publication Type:Review
- Keywords:
autoimmune diseases;
biomarkers;
circRNA;
genetics;
immunology
- MeSH:
Biomarkers;
MicroRNAs/genetics*;
RNA, Circular;
Transcriptome
- From:
Journal of Southern Medical University
2022;42(2):163-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective Circular RNAs (circRNAs) are non-coding RNAs (ncRNA) circularized without a 3' polyadenylation [poly-(A)] tail or a 5' cap, resulting in a covalently closed loop structure. circRNAs were first discovered in RNA viruses in the 1970s, but only a small number of circRNAs were discovered at that time due to limitations in traditional polyadenylated transcriptome analyses. With the development of specific biochemical and computational methods, recent studies have shown the presence of abundant circRNAs in eukaryotic transcriptomes. circRNAs play vital roles in many physiological and pathological processes, such as acting as miRNA sponges, binding to RNA-binding proteins (RBPs), acting as transcriptional regulatory factors, and even serving as translation templates. Current evidence has shown that circRNAs can be potentially used as excellent biomarkers for diagnosis, therapeutic effect evaluation, and prognostic assessment of a variety of diseases, and they may also provide effective therapeutic targets due to their stability and tissue and development-stage specificity. This review focuses on the properties of circRNAs and their immune relationship to disease, and explores the role of circRNAs in immune-related diseases and the directions of future research.
