OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information.

Guosen Zhang; Qiang Wang; Xinlei QI; Huimin Yang; Xiaodong SU; Manman Yang; Chao Jiang; Yang AN; Hong Zheng; Lu Zhang; Wan Zhu; Jiancheng Guo; Xiangqian Guo

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OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information.

Author: Guosen ZHANG ¹ ; Qiang WANG ² ; Xinlei QI ¹ ; Huimin YANG ¹ ; Xiaodong SU ¹ ; Manman YANG ¹ ; Chao JIANG ¹ ; Yang AN ¹ ; Hong ZHENG ¹ ; Lu ZHANG ¹ ; Wan ZHU ³ ; Jiancheng GUO ⁴ ; Xiangqian GUO ⁵
Author Information

1. Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
2. School of Software, Henan University, Kaifeng 475004, China.
3. Department of Anesthesia, Stanford University, Stanford, CA 94305, USA.
4. Department of Molecular Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. gjc@zzu.edu.cn.
5. Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China. xqguo@henu.edu.cn.
Publication Type:Journal Article
Keywords: Head and neck squamous cell carcinoma; Kaplan-Meier curve; OShnscc; Online survival tool; Prognostic biomarker
MeSH: Biomarkers, Tumor/genetics*; Head and Neck Neoplasms/genetics*; Humans; Kaplan-Meier Estimate; RNA; Squamous Cell Carcinoma of Head and Neck; Survival Analysis; Survival Rate
From: Journal of Zhejiang University. Science. B 2022;23(3):249-257
CountryChina
Language:English
Abstract: Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90%) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx. In 2020, approximately 878 ‍ 000 new cases and 444 000 deaths linked to HNSCC occurred worldwide (Sung et al., 2021). Due to the associated frequent recurrence and metastasis, HNSCC patients have poor prognosis with a five-year survival rate of 40%-50% (Jou and Hess, 2017). Therefore, novel prognostic biomarkers need to be developed to identify high-risk HNSCC patients and improve their disease outcomes.