Molecular hydrogen is a promising therapeutic agent for pulmonary disease.
- Author:
Zhiling FU
1
;
Jin ZHANG
2
Author Information
- Publication Type:Journal Article
- Keywords: Inflammation; Molecular hydrogen; Oxidative stress; Pulmonary disease; Reactive oxygen species (ROS)
- MeSH: Acute Lung Injury; Aging; Animals; Anti-Inflammatory Agents; Antioxidants/chemistry*; Asthma/therapy*; Autophagy; COVID-19/therapy*; Humans; Hydrogen/therapeutic use*; Hypertension, Pulmonary/therapy*; Inflammation; Lung Diseases/therapy*; Lung Neoplasms/therapy*; Mice; Oxidative Stress; Pulmonary Disease, Chronic Obstructive/therapy*; Pulmonary Fibrosis/therapy*; Pyroptosis; Reactive Oxygen Species
- From: Journal of Zhejiang University. Science. B 2022;23(2):102-122
- CountryChina
- Language:English
- Abstract: Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants. Short- or long-term exposure to these harmful substances often results in lung injury, causing respiratory and lung diseases. Acute and chronic respiratory diseases have high rates of morbidity and mortality and have become a major public health concern worldwide. For example, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. An increasing number of studies have revealed that hydrogen may protect the lungs from diverse diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, and pulmonary fibrosis. In this review, we highlight the multiple functions of hydrogen and the mechanisms underlying its protective effects in various lung diseases, with a focus on its roles in disease pathogenesis and clinical significance.
