Research progress in atrial fibrillation with cerebral small vessel disease.
10.11817/j.issn.1672-7347.2022.210540
- Author:
Ling JIN
1
;
Yunhai LIU
2
;
Qing HUANG
3
Author Information
1. Department of Neurology, First People's Hospital of Changde City, Changde Hunan 415003. 1171449903@qq.com.
2. Hunan Cerebrovascular Disease Clinical Medical Research Center, Changsha 410008.
3. Hunan Cerebrovascular Disease Clinical Medical Research Center, Changsha 410008. xyneuro@126.com.
- Publication Type:Journal Article
- Keywords:
cerebral small vessel disease;
cognitive function;
ischemic stroke;
neuroimaging;
non-valvular atrial fibrillation
- MeSH:
Aged;
Atrial Fibrillation/epidemiology*;
Cerebral Small Vessel Diseases/complications*;
Cognitive Dysfunction/etiology*;
Humans;
Magnetic Resonance Imaging;
Stroke/etiology*
- From:
Journal of Central South University(Medical Sciences)
2022;47(2):258-264
- CountryChina
- Language:English
-
Abstract:
Non-valvular atrial fibrillation is a common arrhythmia and a major risk factor for cardioembolic stroke. Small cerebral vascular disease is a syndrome of clinical, cognitive, imaging, and pathological manifestations caused by intracranial small vascular lesions. The imaging findings on cranial magnetic resonance usually shows recent subcortical small infarction, vascularised lacunae, white matter hypersignal, perivascular space enlargement, cerebral microhemorrhage, and brain atrophy. It is a major cause of neurological loss and cognitive function decline in the elderly. Current studies suggest that atrial fibrillation may increase the imaging load of cerebral small vessel disease through a series of mechanisms such as microembolization, hypoperfusion, inflammation, endothelial dysfunction, and lymphoid system dysfunction. The imaging of cerebral small vessel disease with atrial fibrillation has a potential relationship with cognitive function decline and is related to the occurrence and prognosis of stroke, even more has a potential role in suggesting the etiology and secondary prevention strategies of ischemic stroke.
