High levels of platelet-to-lymphocyte ratio may predict reduced risk of end stage of renal disease in Chinese patients with MPO-ANCA associated vasculitis.
10.11817/j.issn.1672-7347.2022.210082
- Author:
Li HUANG
1
;
Chanjuan SHEN
2
;
Yong ZHONG
3
;
Joshua D OOI
4
;
Peter J EGGENHUIZEN
4
;
Ya'ou ZHOU
5
;
Jinbiao CHEN
6
;
Ting WU
7
;
Ting MENG
7
;
Zhou XIAO
7
;
Wei LIN
8
;
Rong TANG
7
;
Xiang AO
7
;
Xiangcheng XIAO
7
;
Qiaoling ZHOU
7
;
Ping XIAO
7
Author Information
1. Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008. 617068207@qq.com.
2. Department of Hematology, Affiliated Zhuzhou Hospital Xiangya Medical College, Central South University, Zhuzhou Hunan 412007.
3. Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008. zhongyong121@163.com.
4. Centre for Inflammatory Diseases, Monash University, Clayton, Victoria 3168, Australia.
5. Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha 410008.
6. Department of Medical Records & Information, Xiangya Hospital, Central South University, Changsha 410008.
7. Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008.
8. Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- Keywords:
anti-neutrophil cytoplasmic antibody-associated vasculitis;
end stage of renal disease;
mortality;
myeloperoxidase;
platelet-to-lymphocyte ratio
- MeSH:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis*;
Antibodies, Antineutrophil Cytoplasmic/analysis*;
China/epidemiology*;
Humans;
Kidney Failure, Chronic/complications*;
Lymphocytes;
Peroxidase;
Retrospective Studies
- From:
Journal of Central South University(Medical Sciences)
2022;47(2):211-218
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:Platelet-to-lymphocyte ratio (PLR) has recently been investigated as a new inflammatory marker in many inflammatory diseases, including systemic lupus erythematosus and immunoglobulin A vasculitis. However, there were very few reports regarding the clinical role of PLR in patients with anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis. This study was thus undertaken to investigate the relationship between inflammatory response and disease activity in Chinese patients with myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis. Furthermore, we evaluated whether PLR predicts the progression of end stage of renal disease (ESRD) and all-cause mortality.
METHODS:The clinical, laboratory and pathological data, and the outcomes of MPO-ANCA associated vasculitis patients were collected. The Spearman correlation coefficient was computed to examine the association between 2 continuous variables. Cox regression analysis was used to estimate the association between PLR and ESRD or all-cause mortality.
RESULTS:A total of 190 consecutive patients with MPO-ANCA associated vasculitis were included in this study. Baseline PLR was positively correlated with CRP (r=0.333, P<0.001) and ESR (r=0.218, P=0.003). PLR had no obvious correlation with Birmingham Vasculitis Activity Score (BVAS). Patients having PLR≥330 exhibited better cumulative renal survival rates than those having PLR<330 (P=0.017). However, there was no significant difference in the cumulative patient survival rates between patients with PLR≥330 and those with PLR<330 at diagnosis (P>0.05). In multivariate analysis, PLR is associated with the decreased risk of ESRD (P=0.038, HR=0.518, 95% CI 0.278 to 0.963). We did not find an association between PLR with all-cause mortality using multivariate analysis (HR=1.081, 95% CI 0.591 to 1.976, P=0.801).
CONCLUSIONS:PLR is positively correlated with CRP and ESR. Furthermore, PLR may independently predict the risk of ESRD.
