Anti-hypoxic pharmacological effects of betelnut polyphenols.
10.11817/j.issn.1672-7347.2022.210582
- Author:
Jianghong MA
1
;
Xing DU
2
;
Anpeng ZHAO
3
;
Zihan WANG
3
;
Qianwen GUO
3
;
Ningning QIN
3
;
Rong WANG
4
Author Information
1. Department of Pharmacy, 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050. 1558027798@qq.com.
2. Gansu Institute for Drug Control, Lanzhou 730070, China.
3. Department of Pharmacy, 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050.
4. Department of Pharmacy, 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050. wangrong-69@163.com.
- Publication Type:Journal Article
- Keywords:
anti-hypoxia;
antioxidant;
betelnut polyphenols;
chemical composition
- MeSH:
Antioxidants/pharmacology*;
Areca/chemistry*;
Humans;
Hypoxia;
Oxidative Stress;
Polyphenols/pharmacology*;
Superoxide Dismutase/metabolism*
- From:
Journal of Central South University(Medical Sciences)
2022;47(4):512-520
- CountryChina
- Language:English
-
Abstract:
Areca catechu L. medicinal materials and their preparations are widely used in clinical practice. Betelnut polyphenol is one of the main chemical components with antioxidant, anti-inflammatory, and antibacterial effects. With continuous increase of high altitude activities, tissue oxidative damage caused by high altitude hypoxia seriously affects the ability to work, and the studies on anti-hypoxia drugs are particularly important. Recent studies have shown that betelnut polyphenols have protective effects on oxidative stress injury caused by hypoxia via improving blood gas index of hypoxic organism, increasing superoxide dismutase glutathione catalase activity, and scavenging excessive free radicals. The effects of betelnut polyphenols against hypoxia and oxidative damage protection suggest that betelnut polyphenols can be used as potential anti-hypoxia drugs and posses clinical prospects.
