Role of high-mobility group box 1 in cancer.
10.11817/j.issn.1672-7347.2022.210679
- Author:
Juan XU
1
;
Pengzuo TAO
2
;
Dongjin LÜ
3
;
Yu'e JIANG
2
;
Quansong XIA
4
Author Information
1. Second Department of Internal Medicine, People's Hospital of Guandu District, Kunming 650200. kmxujuan@163.com.
2. Department of Clinical Laboratory, Yunan Cancer Hospital/Third Affiliated Hospital of Kunming Medical University, Kunming 650118.
3. Third Department of Internal Medicine, Yunan Cancer Hospital/Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
4. Department of Clinical Laboratory, Yunan Cancer Hospital/Third Affiliated Hospital of Kunming Medical University, Kunming 650118. xiaquansong@kmmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
dual role;
high-mobility group box 1;
tumor
- MeSH:
Carcinogenesis;
Cell Proliferation;
HMGB1 Protein/metabolism*;
Humans;
Neoplasms/pathology*;
Neovascularization, Pathologic
- From:
Journal of Central South University(Medical Sciences)
2022;47(4):505-511
- CountryChina
- Language:English
-
Abstract:
High-mobility group box 1 (HMGB1) is a non-histone nuclear protein in most eukaryocytes. Inside the nucleus, HMGB1 plays an important role in several DNA events such as DNA repair, transcription, telomere maintenance, and genome stability. While outside the nucleus, it fulfils more complicated functions, including promoting cell proliferation, inflammation, angiogenesis, immune tolerance and immune escape, which may play a pro-tumoral role.Meanwhile, HMGB1 acts as an anti-tumoral protein by regulating immune cell recruitment and inducing immunogenic cell death (ICD) during the carcinogenesis process. Therefore, abnormal expression of HMGB1 is associated with oncogenesis, development, and metastasis of cancer, which may play a dual role of pro-tumor and anti-tumor.
