B cells and tumor immune escape.
10.11817/j.issn.1672-7347.2022.210275
- Author:
Huiting LI
1
;
Guiyuan LI
2
;
Ping XU
3
;
Zheng LI
4
Author Information
1. Cancer Research Institute, Central South University, Changsha 410078. lihuiting@csu.edu.cn.
2. Cancer Research Institute, Central South University, Changsha 410078.
3. Departments of Respiratory and Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen Guangdong 518036, China.
4. Cancer Research Institute, Central South University, Changsha 410078. lizheng@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
B cells;
regulatory B cell;
tertiary lymphoid structure;
tumor immune escape
- MeSH:
B-Lymphocytes/pathology*;
Humans;
Immunotherapy;
Neoplasms/therapy*;
Tumor Escape;
Tumor Microenvironment
- From:
Journal of Central South University(Medical Sciences)
2022;47(3):358-363
- CountryChina
- Language:English
-
Abstract:
B lymphocyte is an important component of the human immune system and it has a role in the process of the body's specific immunity. In recent years, the research on B cells and tumor immune escape has rapidly progressed. Studies have shown that different types of B cells play different roles in tumor microenvironment through a variety of mechanisms. B cells in the tertiary lymphatic structure promote anti-tumor immunity, while regulatory B cells promote tumor immune escape. Antibody drugs targeting B cells are a promising direction for tumor immunotherapy.
