Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospital.
10.1007/s11655-022-3306-4
- Author:
Yang GAO
1
;
Yan-Ming XIE
2
;
Gui-Qian WANG
1
;
Ye-Feng CAI
3
;
Xiao-Ming SHEN
4
;
De-Xi ZHAO
5
;
Ying-Zhen XIE
6
;
Yin ZHANG
1
;
Fan-Xing MENG
7
;
Hai-Qing YU
8
;
Jun-Jie JIANG
1
;
Rui-Li WEI
1
Author Information
1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
2. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China. ktzu2018@163.com.
3. Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, China.
4. Department of Neurology, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China.
5. Department of Neurology, the Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130017, China.
6. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
7. Department of Rehabilitation, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China.
8. Department of Neurology, Taiyuan Hospital of Traditional Chinese Medicine, Taiyuan, 140107, China.
- Publication Type:Multicenter Study
- Keywords:
Chinese medicine hospital;
noncardiogenic ischemic stroke;
onset characteristics;
recurrence
- MeSH:
Aged;
Constriction, Pathologic;
Female;
Hospitals;
Humans;
Hypertension;
Ischemic Stroke;
Male;
Medicine, Chinese Traditional;
Middle Aged;
Prospective Studies;
Stroke/epidemiology*;
Syndrome
- From:
Chinese journal of integrative medicine
2022;28(6):492-500
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in China.
METHODS:A prospective, multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3, 2016 to February 17, 2019. A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk factors. Additionally, stroke recurrence was defined as a primary outcome indicator.
RESULTS:A total of 327 (12.78 %) patients endured recurrence events, 1,681 (65.72%) were men, and the average age was 63.33 ± 9.45 years. Totally 1,741 (68.06%) patients suffered first-ever ischemic stroke, 1,772 (69.27%) patients reported to have hypertension, and 1,640 (64.11%) of them reported dyslipidemia, 1,595 (62.35%) patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Specifically, 1,271 (49.69%) patients were considered as qi-deficient constitution, and 1,227 (47.97%) patients were determined as stagnant blood constitution. There were 1,303 (50.94%) patients diagnosed as blood stasis syndrome, 1,280 (50.04%) patients exhibited phlegm and dampness syndrome and 1,012 (39.56%) patients demonstrated qi deficiency syndrome. And 1,033 (40.38%) patients declared intracranial artery stenosis, and 478 (18.69%) patients reported carotid artery stenosis. The plaque in 1,508 (41.36%) patients were of mixed. Particularly, 41.09% of them demonstrated abnormal levels of glycated hemoglobin levels.
CONCLUSIONS:Recurrence in minor and small-artery stroke cannot be ignored. Hypertension, dyslipidemia, abnormal HbA1c, intracranial artery stenosis and carotid plaque were more common in stroke patients. Particularly, phlegm-dampness and blood stasis syndromes, as well as qi deficiency and blood stasis constitutions, were still the main manifestations of stroke. (Trial registration at ClinicalTrials.gov No. NCT03174535).
