Absorbable Hemostatic Material with High Water Absorption Based on Polysaccharide.
10.3969/j.issn.1671-7104.2022.01.006
- Author:
Hao WU
1
;
Fei PENG
1
;
Jin WANG
1
Author Information
1. Di Kang Zhong Ke Biomedical Materials Co. Ltd., Chengdu, 610000.
- Publication Type:Journal Article
- Keywords:
crosslinked starch;
hemostatic material;
microspheress
- MeSH:
Animals;
Hemostasis;
Hemostatics/pharmacology*;
Polysaccharides/pharmacology*;
Starch/pharmacology*;
Water/pharmacology*
- From:
Chinese Journal of Medical Instrumentation
2022;46(1):28-33
- CountryChina
- Language:Chinese
-
Abstract:
An absorbable hemostatic material based on polysaccharide was prepared. The concentration of blood cells and coagulation factors was increased by reducing the water content in the blood, so as to reduce the coagulation time and achieve the purpose of rapid hemostasis. The specific surface area of starch was increased by using hydrochloric acid to hydrolyze potato starch, which made it easier to combine with α-amylase and increased the degradation rate. Starch was crosslinked into microspheres by crosslinking agent, which made the particle size uniform and greatly improved the water absorption. The surface modification of crosslinked starch microspheres with carboxymethyl group can further improve the water absorption of hemostatic materials. The results showed that the water absorption rate of our hemostatic material was more than 800%, and the average hemostatic time in the animal model was 138.7s. Compared with the imported products on the market, our hemostatic material have better hemostatic performance.
