Simultaneous quantification of pyrethroid metabolites in urine of non-toilet-trained children in Japan.

Jun Ueyama; Yuki Ito; Risa Hamada; Naoko Oya; Sayaka Kato; Taro Matsuki; Hazuki Tamada; Kayo Kaneko; Shinji Saitoh; Mayumi Sugiura-ogasawara; Takeshi Ebara; Michihiro Kamijima

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Simultaneous quantification of pyrethroid metabolites in urine of non-toilet-trained children in Japan.

Author: Jun UEYAMA ¹ ; Yuki ITO ² ; Risa HAMADA ¹ ; Naoko OYA ² ; Sayaka KATO ² ; Taro MATSUKI ² ; Hazuki TAMADA ² ; Kayo KANEKO ² ; Shinji SAITOH ³ ; Mayumi SUGIURA-OGASAWARA ⁴ ; Takeshi EBARA ² ; Michihiro KAMIJIMA ²
Author Information

1. Department of Biomolecular Sciences, Field of Omics Health Sciences, Nagoya University Graduate School of Medicine.
2. Department of Occupational and Environmental Health, Nagoya City University, Graduate School of Medical Sciences.
3. Department of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences.
4. Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medical Sciences.
Publication Type:Journal Article
Keywords: Human biomonitoring; Pyrethroid; Small children; Urine samples
MeSH: Agriculture; Child, Preschool; Environmental Exposure/analysis*; Humans; Infant; Insecticides; Japan; Mass Spectrometry; Pyrethrins/urine*
From:Environmental Health and Preventive Medicine 2022;27(0):25-25
CountryJapan
Language:English
Abstract: BACKGROUND:Pyrethroid (PYR) insecticides are widely used for controlling various pests. There are two types that differ in terms of usage: agricultural-purpose PYR (agriculture-PYR) and hygiene purpose PYR (hygiene-PYRs). Few studies exist on the exposure to these chemicals in small children. In this study, we conducted biomonitoring of urinary pyrethroid metabolites in 1.5-year-old children throughout the year.
METHODS:Study subjects were 1075 children participating in an Aichi regional sub-cohort of the Japan Environment and Children's Study as of 18-month health check-up. The concentrations of four specific hygiene-PYR metabolites including 2,3,5,6-tetrafluoro-1,4-benzenedimethanol (HOCH₂-FB-Al), and five common metabolites of hygiene- and agriculture-PYRs including 3-phenoxybenzoic acid (3PBA) and cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (DCCA), were measured in urine samples extracted from soiled diapers using a triple quadrupole gas chromatograph-mass spectrometer.
RESULTS:The highest detection frequencies were for 3PBA, followed by DCCA, 1R-trans-chrysanthemum dicarboxylic acid, and HOCH₂-FB-Al. Among the six metabolites, urinary concentrations were seasonally varied. However, this variation was not observed in the most studied PYR metabolite, 3PBA. Spearman's correlation analysis demonstrated a significant positive correlation between FB-Al and DCCA (r = 0.56) and HOCH₂-FB-Al and 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol (r = 0.60).
CONCLUSIONS:This biomonitoring survey found widespread and seasonally specific exposure to multiple hygiene- and agriculture-PYRs in 1.5-year-old Japanese children.