The association of family history of herpes zoster and the risk of incident herpes zoster: the SHEZ Study.

Keiko Kinumaki; Hironori Imano; Yukiko Takao; Yoshinobu Okuno; Yasuko Mori; Hideo Asada; Koichi Yamanishi; Hiroyasu Iso

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The association of family history of herpes zoster and the risk of incident herpes zoster: the SHEZ Study.

Author: Keiko KINUMAKI ¹ ; Hironori IMANO ¹ ; Yukiko TAKAO ¹ ; Yoshinobu OKUNO ² ; Yasuko MORI ³ ; Hideo ASADA ⁴ ; Koichi YAMANISHI ⁵ ; Hiroyasu ISO ¹
Author Information

1. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine.
2. Research Institute for Microbial Diseases, Osaka University.
3. Division of Clinical Virology, Kobe University Graduate School of Medicine.
4. Department of Dermatology, Nara Medical University School of Medicine.
5. The Research Foundation for Microbial Diseases of Osaka University.
Publication Type:Journal Article
Keywords: Family history; Herpes zoster; History of HZ; Incidence; Prospective cohort study
MeSH: Female; Herpes Zoster/epidemiology*; Humans; Incidence; Male; Mothers; Proportional Hazards Models
From:Environmental Health and Preventive Medicine 2022;27(0):22-22
CountryJapan
Language:English
Abstract: BACKGROUND:We investigated whether family histories of herpes zoster (HZ) are associated with the risk of incident HZ in a Japanese population.
METHODS:A total of 12,522 Japanese residents aged ≥50 years in Shozu County participated in the baseline survey between December 2008 and November 2009 (the participation rate = 72.3%). They were interviewed at baseline by research physicians regarding the registrants' history of HZ. A self-administered questionnaire survey was conducted to evaluate the potential confounding factors. 10,530 participants without a history of HZ were followed up to ascertain the incidence of HZ during 3-years follow-up until the end of November 2012 with Japanese nationals. We estimated hazard ratios (HRs) of incident HZ according to first-degree family histories using the Cox proportional hazard regression after adjusting for age, sex, and other potential confounding factors.
RESULTS:Compared to no HZ history of each family member, a history of brother or sister was associated with a higher risk of incident HZ while histories of father and mother were not. The multivariable HR (95%CI) of incident HZ for a history of brother or sister was 1.67 (1.04-2.69). When comparing to no family histories of all first-degree relatives, the multivariable HRs (95%CIs) were 1.34 (0.77-2.34) for a history of brother or sister alone, but 4.81 (1.78-13.00) for a history of mother plus brother or sister. As for the number of family histories, the multivariable HRs (95%CIs) were 1.08 (0.76-1.54) for one relative (father, mother, or brother or sister) and 2.75 (1.13-6.70) for two or more relatives.
CONCLUSION:Family histories of mother plus brother or sister and two or more first-degree relatives were associated with a higher risk of incident HZ.