Research Progress of Mesenchymal Stem Cells and Their Exosomes on Tumors.
10.3779/j.issn.1009-3419.2022.101.20
- Author:
Shuyue CUI
1
;
Shuai TANG
1
;
Xiaoling DING
1
;
Gang DING
1
Author Information
1. School of Stomatology, Weifang Medical University, Weifang 261053, China.
- Publication Type:Journal Article
- Keywords:
Cancer;
Exosome;
Mesenchymal stem cells;
Tumor
- MeSH:
Cell Differentiation;
Exosomes;
Humans;
Lung Neoplasms;
Mesenchymal Stem Cells;
Tumor Microenvironment
- From:
Chinese Journal of Lung Cancer
2022;25(5):351-357
- CountryChina
- Language:Chinese
-
Abstract:
In China, malignant tumor is the main cause of death in both urban and rural areas. Mesenchymal stem cells (MSCs) have multidirectional differentiation potential, self-renewal ability and good immunomodulatory properties. Exosomes, as important paracrine substances of MSCs, mediate information exchange and transmission between cells in tumor microenvironment and influence the occurrence and development of tumors. Recently, conflicting findings have been reported on the effects of MSCs and their exosomes on tumors. On the one hand, MSCs and their exosomes are tumorigenic and can target specific sites to inhibit tumor growth; On the other hand, there is also evidence that MSCs could affect tumor growth and migration as part of the tumor microenvironment. In this paper, we will review the relationship between MSCs and exosomes and tumorgenesis and development, as well as how MSCs and exosomes play different roles in tumorgenesis and development, in order to provide beneficial help for tumor diagnosis, prognosis and precise treatment.
.
