Treatment Sequencing Strategies in Lung Cancer.
10.3779/j.issn.1009-3419.2022.104.01
- Author:
Daniel Humberto POZZA
1
;
Ramon Bezerra ANDRADE DE MELLO
2
Author Information
1. Department of Biomedicine, Faculty of Medicine and i3s, University of Porto, 4200-319 Porto, Portugal.
2. Discipline of Medical Oncology, Post-graduation Program in Medicine, Nine of July University (UNINOVE), São Paulo, Brazil./Nine of July Hospital,
São Paulo, Brazil.
- Publication Type:Journal Article
- Keywords:
Atezolizumab;
Brigatinib;
Clinical trials;
Immunotherapy;
Lung neoplasms;
Necitumumab;
Nivolumab;
Pembrolizumab;
Targeted therapies
- MeSH:
Carcinoma, Non-Small-Cell Lung/therapy*;
Early Detection of Cancer;
Humans;
Immunotherapy/methods*;
Lung Neoplasms/therapy*;
Quality of Life
- From:
Chinese Journal of Lung Cancer
2022;25(5):323-336
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:The advances in the lung cancer screening methods and therapeutics, together with awareness towards deleterious habits, such as smoking, is increasing the overall survival with better quality of life for the patients. However, lung cancer is still one of the most common and fatal neoplasm with a high incidence and consequently burden to public health worldwide. Thus, based on guidelines and recent phases II and III clinical trials studies, this manuscript summarizes the current treatment sequencing strategies in lung cancer.
METHODS:A comprehensive search of related articles was performed focused on phases II and III clinical trials studies.
RESULTS:The lung cancer management should take into consideration the tumor characteristics, histology, molecular pathology and be discussed in a multidisciplinary team. Lung cancer treatment options comprises surgery whenever possible, radiotherapy associate with/or chemotherapy and immunotherapy as monotherapy, or combined with chemotherapy and best palliative care.
CONCLUSIONS:The screening predictability in more patients, smoking reduction, early diagnosis, better disease understanding and individualized, more effective and tolerable therapeutics are related to an increasing in overall survival and quality of life. In the near future improvement of personalized therapy in precision medicine is expected, enhancing new predictive biomarkers, optimal doses and optimal treatment sequencing as well as anti-cancer vaccines development.
