Research Status of Tumor-associated Fibroblasts Regulating Immune Cells.
10.3779/j.issn.1009-3419.2022.101.04
- Author:
Guang MU
1
;
Wenhao ZHANG
1
;
Jingjing HUANG
1
;
Zhipeng CHEN
1
;
Jun WANG
1
Author Information
1. Department of Thoracic Surgery, The First Clinical Medical College of Nanjing Medical University, Nanjing 210000, China.
- Publication Type:Review
- Keywords:
Immunoregulation;
Tumor immunity;
Tumor microenvironment;
Tumor-associated fibroblast;
Tumor-infiltrating immune cells
- MeSH:
Cancer-Associated Fibroblasts/metabolism*;
Carcinogenesis;
Cell Transformation, Neoplastic/metabolism*;
Humans;
Lung Neoplasms/metabolism*;
Tumor Microenvironment
- From:
Chinese Journal of Lung Cancer
2022;25(3):207-213
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts (CAFs) and tumor-infiltrating immune cells are the most essential components of the tumor microenvironment (TME). They communicate with each other in tumor microenvironment and play a critical role in tumorigenesis and development. CAFs are very heterogeneous and different subtypes of CAFs display different functions. At the same time, it can contribute to the regulation of the function of tumor-infiltrating immune cells and eventually result in the carcinogenesis, tumor progression, invasion, metastasis and other biological behaviors of tumors by producting various growth factors and cytokines etc. Based on the current research results at home and abroad, this paper reviews the recent research progress on the regulation of CAFs on infiltrating immune cells in tumor microenvironment.
.
