Strategic Exploration of Targeted Therapy for BRAF Non-V600E Mutant Lung Cancer.
10.3779/j.issn.1009-3419.2021.101.51
- Author:
Hongxia ZHANG
1
;
Jinsheng GAO
2
;
Wei GUO
3
;
Bo YU
4
;
Haitao YANG
1
;
Yutao LIU
5
Author Information
1. Department of General Practice, Liaocheng People's Hospital, Liaocheng 252000, China.
2. Department of Medical Oncology, Yilong People's Hospital, Nanchong 637000, China.
3. Family ward Department, Liaocheng Fourth People's Hospital, Liaocheng 252000, China.
4. The Department of Pulmonary and Critical Care Medicine, Liaocheng People's Hospital, Liaocheng 252000, China.
5. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing 100021, China.
- Publication Type:Review
- Keywords:
BRAF non-V600E mutant;
Lung neoplasms;
Targeted therapy
- MeSH:
Animals;
Antineoplastic Combined Chemotherapy Protocols/therapeutic use*;
Carcinoma, Non-Small-Cell Lung/drug therapy*;
Humans;
Lung Neoplasms/genetics*;
Mice;
Mutation;
Protein Kinase Inhibitors/therapeutic use*;
Proto-Oncogene Proteins B-raf/genetics*
- From:
Chinese Journal of Lung Cancer
2022;25(2):86-91
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Dabrafenib+Trametinib/Dabrafenib targeted therapy has been approved for V-RAF murine sarcoma viral oncogene homolog B1 with amino acid substitution for valine at position 600 (BRAF V600E) in lung cancer patients, however, the targeted therapy strategy for lung cancer patients with BRAF non-V600E mutations has not been determined yet. This study intends to explore the efficacy of targeted therapy for BRAF non-V600E mutant lung cancer, and provide a reference for clinical treatment.
METHODS:Computer search of PubMed, Cochrane Library, Embase, Web of Science, Clinicaltrials.gov, CBM, CNKI, Wanfang database. Collect the relevant literature relevant on the targeted therapy of BRAF non-V600E mutant lung cancer, and conduct a descriptive analysis of the included literature.
RESULTS:There were 10 articles that met the inclusion criteria, including 3 cohort studies and 7 case reports. 18 patients with BRAF non-V600E mutant lung cancer were ineffective to vermurafenib; 1 patient obtained partial response (PR) after applying vermurafenib, 5 patients did not respond to BRAF inhibitors; 9 patients showed a potential clinical benefit rate of 34% after monotherapy with trametinib; 7 patients have different degrees of benefit from dabrafenib and trametinib on progression-free survival (PFS); 1 patient is effective to sorafenib.
CONCLUSIONS:At present, there is no standard treatment specification for BRAF non-V600E mutation targeted therapy. The challenge lies in the heterogeneous mutation of BRAF gene. Different mutation types respond differently to targeted therapy. In addtion, real-world research evidence is scarce, so it is necessary to carry out further large-sample high-quality research to provide reference for clinical practice.
