Advances in the Study of Tumor-associated Macrophages in Lung Cancer.
10.3779/j.issn.1009-3419.2021.102.49
- Author:
Yanyan QIAO
1
;
Enqing FU
1
Author Information
1. Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Air Force Military Medical University,
Xi'an 710038, China.
- Publication Type:Review
- Keywords:
Lung neoplasms;
Tumor microenvironment;
Tumor-associated macrophages
- MeSH:
Endothelial Cells;
Humans;
Immunotherapy;
Lung Neoplasms/therapy*;
Tumor Microenvironment;
Tumor-Associated Macrophages
- From:
Chinese Journal of Lung Cancer
2022;25(1):34-39
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the malignant tumors with the highest morbidity and mortality in China. Therefore, the research on the treatment of lung cancer is also deepening. At present, there are mainly systemic chemotherapy, targeted therapy for positive driver genes, the application of immune checkpoint inhibitors, anti-tumor angiogenesis therapy and the combination of the different treatment methods mentioned above. The use of these regimens has significantly improved the prognosis of most lung cancer patients, but the prognosis of patients with advanced lung cancer remains unsatisfactory. Recently, more and more attention has been paid to the study of tumor microenvironment (TME). TME consists of immune cells, fibroblasts, vascular endothelial cells and other cellular components as well as related cytokines, which is the basis for the survival and development of tumor cells. As an important immune cell of TME, tumor-associated macrophages (TAMs) refer to macrophages infiltrating in tumor tissues, which can promote tumor cell proliferation, induce tumor immune tolerance, stimulate tumor angiogenesis, and increase the invasion and metastasis ability of tumor cells. Therefore, targeting TAMs has become a hot topic in lung cancer immunotherapy. In this review, the sources, phenotypes, mechanisms of TAMs in lung cancer, as well as future therapeutic targets of TAMs were reviewed to provide reference for optimal treatment of lung cancer.
.
