Research Progress of HO1 on AntiOxidative Stress Injury of MSC --Review.
10.19746/j.cnki.issn.1009-2137.2022.02.048
- Author:
Li Ping ZHAO
1
;
Xiao Yan LI
2
;
Hai BAI
3
Author Information
1. The Second Clinical Medical College of Lanzhou University, Lanzhou 730030, Gansu Province, China,Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China.
2. Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China.
3. Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China,Email：baihai98@tom.com.
- Publication Type:Journal Article
- Keywords:
antiapoptosis;
antioxidation;
heme oxygenase 1;
mesenchymal stem cells
- MeSH:
Apoptosis;
Cell Differentiation;
Heme Oxygenase-1/metabolism*;
Humans;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stem Cells;
Oxidative Stress
- From:
Journal of Experimental Hematology
2022;30(2):613-617
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cell (MSC) is widely used in cell therapy because of its high proliferative and multi directional differentiation potential as well as its low immunogenicity. The transplantation of MSC can help the repair of the injured organs, however, the MSC transplanted to the local organs are affected by oxidative stress and lead to premature aging or apoptosis. Heme oxygenase 1 (HO1) is a key ratelimiting enzyme in the process of heme metabolism, which has the functions of antiinflammation, antioxidation, antiapoptosis, antiaging, reducing cell damage and promoting angiogenesis. Induced high expression of HO1 in MSC could increase the ability of MSC against oxidative stress injury, delay the senescence and apoptosis of MSC, and alleviate cell injury. In this reviews, the research progress of HO1 on antioxidative stress injury of MSC.
