Comparision of Allogeneic Hematopoietic Stem Cell Transplantation between Children with Thalassemia of Different Ages.
10.19746/j.cnki.issn.1009-2137.2022.02.036
- Author:
Dong-Liang KANG
1
,
2
;
Yong-Hong TAN
3
,
4
;
Ya-Mei CHEN
4
;
Jing-Yuan LU
4
;
Jie SHI
4
;
Xiu-Zhen YAN
4
;
Quan-Yi LU
3
,
5
Author Information
1. Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, Fujian Province, China
2. The School of Clinical Medicine, Fujian Medical University, Fuzhou 350122, Fujian Province, China.
3. The School of Clinical Medicine, Fujian Medical University, Fuzhou 350122, Fujian Province, China
4. Department of Hematology, Zhongshan Hospital, Xiamen University, Xiamen 361004, Fujian Province, China.
5. Department of Hematology, Zhongshan Hospital, Xiamen University, Xiamen 361004, Fujian Province, China,E-mail: quanyilu@hotmail.com.
- Publication Type:Journal Article
- Keywords:
age;
allogeneic hematopoietic stem cell transplantation;
complication;
efficacy;
thalassemia
- MeSH:
Child;
Child, Preschool;
Graft vs Host Disease/complications*;
Hematopoietic Stem Cell Transplantation;
Humans;
Quality of Life;
Retrospective Studies;
Thalassemia/therapy*;
beta-Thalassemia/therapy*
- From:
Journal of Experimental Hematology
2022;30(2):539-542
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the difference of therapeutic effects on children with thalassemia at different age after hematopoietic stem cell transplantation.
METHODS:The clinical data of children with thalassemia treated in our hospital were retrospectively analyzed. The children were divided into 2-5 years old group and 6-12 years old group. The success rate of implantation, transplant-related mortality, GVHD incidence, and other transplant-related complications, as well as thalassemia-free survival (TFS) were compared between the two groups.
RESULTS:The incidence of GVHD, hemorrhagic cystitis and severe oral mucositis after transplantation in the 2-5 years old group were significantly lower than those in the 6-12 years old group, while there was no statistically significant difference in the TFS between the two groups.
CONCLUSION:Children in the low age (2-5 years old) group show fewer complications and higher quality of life after transplantation, therefore, stem cell transplantation at 2-5 years old is more conducive to rehabilitation of the children with thalassemia.
