Clinical Diagnosis and Prenatal Screening of Hb Lepore-BW Associated with IVS-II-654 Heterozygous Mutation.
10.19746/j.cnki.issn.1009-2137.2022.02.034
- Author:
Hui-Li BAI
1
;
Wei CHENG
1
;
Jin CUI
1
;
Rong LI
2
;
Ying LI
1
;
Jun XIAO
1
;
Yu-Hong ZHANG
3
Author Information
1. The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
2. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
3. The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China,E-mail: zhangyuhong0730@126.com.
- Publication Type:Journal Article
- Keywords:
Hb Lepore-BW;
abnormal hemoglobin;
prenatal screening;
thalassemia
- MeSH:
Female;
Hemoglobins, Abnormal/genetics*;
Heterozygote;
Humans;
Infant, Newborn;
Male;
Mutation;
Pregnancy;
Prenatal Diagnosis;
beta-Thalassemia/genetics*
- From:
Journal of Experimental Hematology
2022;30(2):529-533
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To identify one case of rare Hb Lepore-BW associated with IVS-II-654 heterozygous mutation in Sichuan area.
METHODS:The blood routine examination and hemoglobin electrophoresis methods were used to analyze the blood routine parameters, HbA2 and HbF in the samples of peripheral blood in proband and his parents, as well as the cord blood of pregnant woman. The detection of thalassemia gene and Sanger sequencing methods were used to detect the hemoglobin mutations.
RESULTS:The result showed that the Hb Lepore-BW heterozygous mutation was detected in the father of the proband, while a rare Hb Lepore-BW with IVS-II-654 heterozygous mutation was detected in the proband, as well as his mother and cord blood were both detected as IVS-II-654 heterozygous mutation.
CONCLUSION:The study identified a rare Hb Lepore-BW with IVS-II-654 heterozygous mutation, which was characterized by intermediate β-thalassemia. It is necessary to hemoglobin electrophoresis combined with routine blood testing in prenatal screening.
